Successful Treatment of Pembrolizumab-Induced Severe Capillary Leak Syndrome and Lymphatic Capillary Dysfunction

Pulmonary Capillary Leak Syndrome

Successful treatment of systemic capillary leak syndrome with intravenous immunoglobulins.

posteriormente leveriracetam y gabapentina en el manejo del status epiléptico en pacientes con PAI. Sin embargo, ningún fármaco debiera ser descartado por completo si su uso resultase esencial. Con frecuencia tras el diagnóstico nos encontramos con fármacos considerados no seguros sin efectos adversos. No obstante, es importante recordar su posible interacción futura con otros fármacos que pudi...

Gemcitabine-induced systemic capillary leak syndrome.

Systemic capillary leak syndrome (SCLS) is a rare disorder with a high mortality rate, characterized by rapidly developing edema, weight gain and hypotension, hemoconcentration and hypoproteinemia. This syndrome is caused by sudden, reversible capillary hyperpermeability with a rapid extravasation of plasma from the intravascular to the interstitial space. Even though SCLS has been suggested to...

Systemic capillary leak syndrome.

A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-lambda. She had had a similar episode of generalized edema 2 years previously. We diagnosed the patient as having typical systemic capillary leak syndrome (SCLS) and she impr...

SyStemic capillary leak Syndrome

Results: Of the 34 patients whose records were reviewed, 25 fulfilled all diagnostic criteria for SCLS. The median age at diagnosis of SCLS was 44 years. Median follow-up of surviving patients was 4.9 years, and median time to diagnosis from symptom onset was 1.1 years (interquartile range, 0.5-4.1 years). Flulike illness or myalgia was reported by 14 patients (56%) at onset of an acute attack ...